Transdiagnostic interventions have been shown to be effective in improving quality of life (QoL) among cancer survivors. This narrative review aims to explore the impact of transdiagnostic interventions on QoL to facilitate development of more effective interventions and future research. A comprehensive literature search was conducted in the PubMed database using a combination of MeSH terms and keywords related to cancer survivorship, QoL, and transdiagnostic interventions. Studies on Metacognitive therapy (MCT) and ConquerFear demonstrated promising results in reducing emotional distress, improving QoL, and managing fear of cancer recurrence (FCR). Both interventions demonstrated high completion rates, suggesting acceptability among cancer survivors. MCT included metacognitive beliefs and processes, empowering participants to manage negative thoughts and feelings. ConquerFear, delivered individually or in group formats, including online, effectively reduced FCR and anxiety, with sustained benefits over time. Integrating transdiagnostic approaches into survivorship care holds promise for enhancing QoL and well-being for cancer survivors. Although these findings highlight the potential of transdiagnostic interventions, further research is needed to explore patient characteristics influencing treatment outcomes and to optimize intervention delivery.